2019
Adhesion and growth factor receptor crosstalk mechanisms controlling cell migration
Self-Assembling Proteins as High-Performance Substrates for Embryonic Stem Cell Self-Renewal
2018
Integrin αVβ6-EGFR crosstalk regulates bidirectional force transmission and controls breast cancer invasion
Nikki R Paul#, Joanna R Thomas#, Horacio Maldonado, Katarzyna I Wolanska, Ewa J Koper, Jonathan D Humphries, Adam Byron, Adams George, Nathan Allen, Ian A Prior, Charles H Streuli, Martin J Humphries, Mark R Morgan†
2017
Regulation of vascular smooth muscle cell calcification by syndecan-4/FGF-2/PKCα signaling and cross-talk with TGFβ
Pro-migratory and TGF-β-activating functions of αvβ6 integrin in pancreatic cancer are differentially regulated via an Eps8-dependent GTPase switch
Pro-migratory and TGF-β-activating functions of αvβ6 integrin in pancreatic cancer are differentially regulated via an Eps8-dependent GTPase switch (2017)
The Journal of pathology, 243 (1): 37-50. DOI: 10.1002/path.4923
2016
PPFIA1 drives active α5β1 integrin recycling and controls fibronectin fibrillogenesis and vascular morphogenesis
Mana, Giulia, Clapero, Fabiana, Panieri, Emiliano, Panero, Valentina, Bottcher, Ralph T, Tseng, Hui-Yuan, Saltarin, Federico, Astanina, Elena, Wolanska, Katarzyna I, Morgan, Mark R, Humphries, Martin J, Santoro, Massimo M, Serini, Guido and Valdembri, Donatella.
PPFIA1 drives active a5b1 integrin recycling and controls fibronectin fibrillogenesis and vascular morphogenesis (2016) Nature Communications, 7:13546. DOI: 10.1038/ncomms13546
2015
Emerging properties of adhesion complexes: What are they and what do they do?
Humphries, Jonathan, Paul, Nikki, Humphries, Martin and Morgan, Mark R.
Emerging properties of adhesion complexes: What are they and what do they do? (2015) Trends in Cell Biology, 25 (7). pp 388-97. DOI: 10.1016/j.tcb.2015.02.008
Fibronectin remodelling: cell-mediated regulation of the microenvironment
Fibronectin remodelling: cell-mediated regulation of the microenvironment. (2015) Biochemical Society Transactions, 43 (1). pp. 122-128. ISSN 0300-5127
2013
Rac1 is deactivated at integrin activation sites via an IQGAP1/filamin-A/RacGAP1 pathway
Jacquemet, Guillaume, Morgan, Mark R, Byron, Adam , Humphries, Jonathan D , Choi, Colin K , Chen, Christopher S , Caswell, Patrick T and Humphries, Martin J (2013)
Rac1 is deactivated at integrin activation sites via an IQGAP1/filamin-A/RacGAP1 pathway. Journal of Cell Science, 126 (18). pp. 4121-4135. DOI: 10.1242/jcs.121988
Syndecan-4 Phosphorylation Is a Control Point for Integrin Recycling
Morgan, Mark R, Hamidi, Hellyeh, Bass, Mark D, Warwood, Stacey, Ballestrem, Christoph and Humphries, Martin J (2013)
Syndecan-4 Phosphorylation Is a Control Point for Integrin Recycling. Developmental Cell, 24 (5). pp. 472-485. DOI: 10.1016/j.devcel.2013.01.027
2011
A Syndecan-4 Hair Trigger Initiates Wound Healing through Caveolin- and RhoG-Regulated Integrin Endocytosis
Bass, Mark D, Williamson, Rosalind C, Nunan, Robert D, Humphries, Jonathan D, Byron, Adam, Morgan, Mark R, Martin, Paul and Humphries, Martin J (2011)
A Syndecan-4 Hair Trigger Initiates Wound Healing through Caveolin- and RhoG-Regulated Integrin Endocytosis. Developmental Cell, 21 (4). pp. 681-693. DOI: 10.1016/j.devcel.2011.08.007
Psoriasin (S100A7) associates with integrin β6 subunit and is required for αVβ6-dependent carcinoma cell invasion
Morgan, Mark R, Jazayeri, Mona, Ramsay, Alan G, Thomas, Gareth J, Boulanger, Martin J, Hart, Ian R and Marshall, John F (2011)
Psoriasin (S100A7) associates with integrin β6 subunit and is required for αVβ6-dependent carcinoma cell invasion. Oncogene, 30 (12). pp. 1422-1435. DOI: 10.1038/onc.2010.535
2010
Adhesion signalling complexes
Byron*, Adam, Morgan*, Mark R and Humphries, Martin J (2010)
Adhesion signalling complexes. Current Biology, 20 (24). pp. 1063-1067. Asterisks (*) denote equal contribution DOI: 10.1016/j.cub.2010.10.059
2009
Giving off mixed signals – distinct functions of α5β1 and αVβ3 integrins in regulating cell behaviour
Morgan, Mark R, Byron, Adam, Humphries, Martin J and Bass, Mark D (2009)
Giving off mixed signals–distinct functions of α5β1 and αVβ3 integrins in regulating cell behaviour. IUBMB Life, 61 (7). pp. 731-738. DOI: 10.1002/iub.200
Syndecans shed their reputation as inert molecules
Bass, Mark D*, Morgan, Mark R* and Humphries, Martin J (2009)
Syndecans shed their reputation as inert molecules. Science Signaling, 2 (64). pe18. Asterisks (*) denote equal contribution DOI: 10.1126/scisignal.264pe18
Therapeutic Ultrasound Bypasses Canonical Syndecan-4 Signaling to Activate Rac1
Mahoney, Claire M, Morgan, Mark R, Harrison, Andrew, Humphries, Martin J and Bass, Mark D (2009)
Therapeutic Ultrasound Bypasses Canonical Syndecan-4 Signaling to Activate Rac1. The Journal of Biological Chemistry, 284 (13). pp. 8898-8909. DOI: 10.1074/jbc.M804281200
2008
p190RhoGAP is the convergence point of adhesion signals from α5β1 integrin and syndecan-4
Bass, Mark D, Morgan, Mark R, Roach, Kirsty A, Settleman, Jeffrey, Goryachev, Andrew B and Humphries, Martin J (2008)
p190RhoGAP is the convergence point of adhesion signals from α5β1 integrin and syndecan-4. The Journal of Cell Biology, 181 (6). pp. 1013-1026. DOI: 10.1083/jcb.200711129
2007
Integrins and syndecan-4 make distinct, but critical, contributions to adhesion contact formation
Bass, Mark D, Morgan, Mark R and Humphries, Martin J (2007)
Integrins and syndecan-4 make distinct, but critical, contributions to adhesion contact formation. Soft Matter, 3 (3). pp. 372-376. DOI: 10.1039/b614610d
Syndecan-4-dependent Rac1 regulation determines directional migration in response to the extracellular matrix
Bass, Mark D, Roach, Kirsty A, Morgan, Mark R, Mostafavi-Pour, Zohreh, Schoen, Tobias, Muramatsu, Takashi, Mayer, Ulrike, Ballestrem, Christoph, Spatz, Joachim P and Humphries, Martin J (2007)
Syndecan-4-dependent Rac1 regulation determines directional migration in response to the extracellular matrix. The Journal of Cell Biology, 177 (3). pp. 527-538.DOI: 10.1083/jcb.200610076
Synergistic control of cell adhesion by integrins and syndecans
Morgan, Mark R, Humphries, Martin J and Bass, Mark D (2007)
Synergistic control of cell adhesion by integrins and syndecans. Nature Reviews Molecular Cell Biology, 8 (12). pp. 957-969.DOI: 10.1038/nrm2289
2005
Integrin-Syndecan Cooperation Governs the Assembly of Signalling Complexes during Cell Spreading
Humphries, Martin J, Mostafavi-Pour, Zohreh, Morgan, Mark R, Deakin, Nicholas O, Messent, Anthea J and Bass, Mark D (2005)
Integrin-Syndecan Cooperation Governs the Assembly of Signalling Complexes during Cell Spreading. In: Signalling Networks in Cell Shape and Motility: Novartis Foundation Symposium 269.DOI: 10.1002/047001766X.ch14
2004
Modulation of the urokinase-type plasminogen activator receptor by the β6 integrin subunit
Dalvi, Nafisa, Thomas, Gareth J, Marshall, John F, Morgan, Mark R, Bass, Rosemary, Ellis, Vincent, Speight, Paul M and Whawell, Simon A (2004)
Modulation of the urokinase-type plasminogen activator receptor by the β6 integrin subunit. Biochemical and Biophysical Research Communications, 317 (1). pp. 92-99.DOI: 10.1016/j.bbrc.2004.02.178
Reduction of TSG101 protein has a negative impact on tumor cell growth
Zhu, Gang, Gilchrist, Ruth, Borley, Nigel, Chng, Hsiao Wee, Morgan, Mark R, Marshall, John F, Camplejohn, Richard S, Muir, Gordon H and Hart, Ian R (2004)
Reduction of TSG101 protein has a negative impact on tumor cell growth. International Journal of Cancer, 109 (4). pp. 541-547.DOI: 10.1002/ijc.20014
The integrin cytoplasmic-tail motif EKQKVDLSTDC is sufficient to promote tumor cell invasion mediated by matrix metalloproteinase (MMP)-2 or MMP-9
Morgan, Mark R, Thomas, Gareth J, Russell, Alan, Hart, Ian R and Marshall, John F (2004) The integrin cytoplasmic-tail motif EKQKVDLSTDC is sufficient to promote tumor cell invasion mediated by matrix metalloproteinase (MMP)-2 or MMP-9. The Journal of Biological Chemistry, 279 (25). pp. 26533-26539.DOI: 10.1074/jbc.M401736200
2002
Patent: Biologically Active Molecules
Patent: Biologically Active Molecules. Patent No: GB0216343A
Morgan Lab 